AviadoBio

Clinical Trials

DELIVERING THE FUTURE OF GENE THERAPY

At AviadoBio, our mission is to transform the lives of people living with devastating neurodegenerative diseases such as frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

Our clinical development program is built on the research of our co-founders and world-leading scientists. We work with an extensive network of leading neurologists, neurosurgeons and disease experts to evaluate our investigational gene therapies.

INVESTIGATIONAL GENE THERAPY AVB-101

AVB-101 is an investigational, adeno-associated virus-based (AAV) gene supplementation therapy for FTD patients with disease-causing mutations in the GRN gene. Designed as a one-time therapy to potentially halt disease progression, it delivers a functional copy of the GRN gene to restore progranulin levels in the brain. It is delivered by an intrathalamic infusion for targeted biodistribution with the aim to limit the treatment to only the brain itself, where it is needed. AVB-101 has been granted orphan designation by the US FDA and European Commission.

A Phase 1/2 open-label clinical study to evaluate the safety and preliminary efficacy of AVB-101 in people with a genetic sub-type of frontotemporal dementia (FTD-GRN)

“Being relentless means always striving for the best implementation of our plans and ensuring we deliver as individuals, and as a company as whole. We know that patients have limited options and time. Even when the path may not be clear, we navigate a way forward by being bold and tenacious in our decision making.”

David Cooper, MD

Chief Medical Officer

Aviadobio team david cooper

David Cooper, MD

Chief Medical Officer

AviadoBio policy on expanded access to investigational therapies

ABOUT US

Learn more about our mission to transform lives and our industry-leading team

SCIENCE & DELIVERY

Find out more about how we are progressing innovative gene therapies to potentially treat neurodegenerative disease. 

CAREERS

When you join AviadoBio, you join more than just a company, you join a dedicated team with a clear mission

 

CONTACT

We’d love to hear from you. If you have an enquiry about our gene therapies, delivery systems or clinical trials please contact us using the details here